| Pair Name | Beta-Elemene, Etoposide | ||
| Phytochemical Name | Beta-Elemene (PubChem CID: 6918391 ) | ||
| Anticancer drug Name | Etoposide (PubChem CID: 36462 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Beta-Elemene, Etoposide | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. Mol Med Rep. 2011 Nov-Dec;4(6):1189-93. doi: 10.3892/mmr.2011.537. | Click |
